Thymulin
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Overview
Thymulin (Serum Thymic Factor, FTS) is a nonapeptide (9-amino acid) thymic hormone that requires zinc as a cofactor for biological activity. It is one of the key hormones produced by thymic epithelial cells and plays an essential role in T-cell maturation, differentiation, and immune system regulation.
Mechanism of Action
Thymulin binds to specific receptors on T-cell precursors, promoting their differentiation into mature functional T-cells. The zinc-thymulin complex is the active form; zinc binding induces the conformational change necessary for receptor recognition. Thymulin levels decline with thymic involution during aging, contributing to age-related immune decline.
Research Context
Thymulin levels in circulation decrease dramatically after puberty as the thymus involutes. This decline correlates with reduced T-cell function and increased susceptibility to infections and autoimmune conditions in aging. Zinc supplementation can partially restore thymulin activity.
Key Research Areas
Considerations for Researchers
Requires zinc for activity. Limited vendor base. Store lyophilized at -20C. Ensure zinc status is accounted for in research protocols.
Disclaimer: All information on this page is for research purposes only and is not intended as medical advice. Peptide research should be conducted by qualified professionals in appropriate laboratory settings. Pushing Peptides does not sell peptides. We aggregate publicly available pricing and vendor data.