SLU-PP-332 (Tablets)

Overview

SLU-PP-332 is a synthetic ERR (Estrogen-Related Receptor) agonist classified as an "exercise mimetic" compound. It activates the same transcriptional programs that exercise triggers, particularly in skeletal muscle, without requiring physical activity. Available in tablet form for oral administration research.

Mechanism of Action

SLU-PP-332 activates all three ERR isoforms (ERRalpha, ERRbeta, ERRgamma), which are key transcription factors that regulate mitochondrial biogenesis, fatty acid oxidation, and oxidative metabolism in muscle. ERRs are normally activated by exercise through PGC-1alpha signaling. SLU-PP-332 bypasses this upstream signal and directly engages the transcriptional machinery.

Research Context

Published research has shown that SLU-PP-332 treatment in animal models increases fatigue resistance, enhances mitochondrial function in skeletal muscle, and reduces body fat. It represents a novel approach to metabolic research by targeting transcriptional programs rather than individual enzymes or receptors.

Key Research Areas

Considerations for Researchers

Available primarily in tablet form for oral bioavailability studies. Relatively new to the research peptide market with a smaller vendor base. Limited long-term data. Verify compound identity and purity via analytical testing.