CJC-1295 (no DAC)

Overview

CJC-1295 without DAC (also called Modified GRF 1-29) is a synthetic GHRH analog with four amino acid substitutions that improve metabolic stability compared to native GHRH. Without the Drug Affinity Complex, it has a half-life of approximately 30 minutes, producing acute GH pulses rather than sustained elevation.

Mechanism of Action

CJC-1295 no DAC binds to GHRH receptors on pituitary somatotroph cells, triggering a sharp pulse of growth hormone release that mimics the natural pulsatile GH secretion pattern. The four amino acid substitutions (at positions 2, 8, 15, 27) protect against enzymatic degradation by DPP-IV and other peptidases without fundamentally altering the pharmacodynamic profile.

Research Context

The no-DAC version is generally preferred in research protocols that aim to study pulsatile GH release, as it better approximates physiological GH secretion patterns. It is commonly paired with Ipamorelin for synergistic effects.

Key Research Areas

Considerations for Researchers

Do not confuse with CJC-1295 with DAC, which has fundamentally different pharmacokinetics. The no-DAC version requires more frequent administration due to its shorter half-life. Store at -20C lyophilized.