5-Amino-1MQ

Overview

5-Amino-1MQ (5-Amino-1-Methylquinolinium) is a small molecule NNMT (Nicotinamide N-Methyltransferase) inhibitor being investigated for its role in metabolic regulation and fat cell biology. While technically not a peptide, it is commonly listed alongside peptides in the research community due to overlapping use cases.

Mechanism of Action

NNMT is an enzyme that methylates nicotinamide, diverting it away from the NAD+ salvage pathway and depleting cellular NAD+ levels. By inhibiting NNMT, 5-Amino-1MQ increases intracellular NAD+ availability, which activates SIRT1 and AMPK signaling. In adipocytes, NNMT inhibition reduces fat storage and promotes a more metabolically active phenotype. NNMT is overexpressed in white adipose tissue of obese individuals, making it a compelling metabolic target.

Research Context

Studies have shown that NNMT inhibition with 5-Amino-1MQ reduces body weight and adiposity in diet-induced obesity models without affecting food intake. This suggests a mechanism of action centered on energy expenditure and fat cell metabolism rather than appetite suppression.

Key Research Areas

Considerations for Researchers

Available in both injectable and tablet formulations. The tablet form (5-Amino-1MQ Tablets) offers oral bioavailability. Price ranges vary significantly between forms. Not a peptide per se, but commonly grouped with peptides in vendor catalogs.