Weight Loss

Cagrilintide

Price Range

$0.10 – $44.80/mg

Vendors

20

Views

5

Fat LossAppetite ControlSatiety SupportWeight LossMetabolic Support

Where to Buy

Compare Cagrilintide prices across verified vendors. Affiliate links support Pushing Peptides.

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Midwest PeptideVerifiedCoupon Available

Price/mg

$9.00

Vial

10mg

Price

$90.00

GenpeptideVerifiedCoupon Available

Price/mg

$8.00

Vial

5mg

Price

$40.00

EZ PeptidesVerifiedCoupon Available

Price/mg

$8.80

Vial

5mg

Price

$44.00

Ameano PeptidesVerifiedCoupon Available

Price/mg

$8.80

Vial

10mg

Price

$88.00

Price/mg

$9.00

Vial

10mg

Price

$90.00

Price/mg

$0.10

Vial

10mg

Price

$1.00

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Overview

Cagrilintide is a long-acting acylated amylin analog designed for once-weekly administration. Amylin is a peptide co-secreted with insulin from pancreatic beta cells that plays a critical role in glucose homeostasis and appetite regulation. Cagrilintide's extended half-life makes it a practical research tool for studying sustained amylin receptor activation.

Mechanism of Action

Cagrilintide activates amylin receptors (AMY1, AMY2, AMY3), which are heterodimers of the calcitonin receptor with receptor activity-modifying proteins (RAMPs). Amylin receptor activation slows gastric emptying, suppresses postprandial glucagon secretion, and activates satiety circuits in the area postrema and nucleus of the solitary tract. The fatty acid modification (acylation) enables albumin binding, extending the circulatory half-life.

Research Context

Clinical trials of cagrilintide, both as monotherapy and in combination with semaglutide (CagriSema), have shown robust weight reduction and glycemic improvement. The amylin pathway is complementary to GLP-1, making combinations particularly effective.

Key Research Areas

Amylin receptor pharmacology and RAMP isoform selectivity
Complementary mechanisms with GLP-1 agonists
Central satiety signaling in the hindbrain
Gastric emptying kinetics and nutrient absorption
Beta-cell function preservation in metabolic models

Considerations for Researchers

The acylation modification means standard peptide handling applies, but the larger modified peptide may require verification of acylation integrity. Store at -20C lyophilized.

Disclaimer: All information on this page is for research purposes only and is not intended as medical advice. Peptide research should be conducted by qualified professionals in appropriate laboratory settings. Pushing Peptides does not sell peptides. We aggregate publicly available pricing and vendor data.